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BioTechnology QUESTION #10582
Question 1
Baffles in a stirred tank bioreactor serve primarily to:
  • Increase the working volume of the vessel
  • Prevent vortexing and improve radial mixing efficiency✔️
  • Reduce oxygen transfer by limiting turbulence
  • Separate the riser from the downcomer zone
Correct Answer Explanation
Baffles are vertical plates projecting from the vessel wall (typically 4 baffles, width = D_tank/10–12) that break the tangential swirling flow caused by impeller rotation. Without baffles, liquid rotates as a solid body (vortex), producing poor mixing and reduced gas dispersion. Baffles convert rotational energy into radial and axial flow, dramatically improving mixing homogeneity and oxygen transfer efficiency.