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CSS Zoology QUESTION #1338
Question 1
Which co-enzyme is NOT involved in oxidative decarboxylation of pyruvic acid?
  • CoA-SH
  • \(\text{Mg}^{2+}\)
  • Biotin✔️
  • None of these
Correct Answer Explanation
The oxidative decarboxylation of pyruvate to acetyl-CoA (by pyruvate dehydrogenase complex) requires five coenzymes: CoA-SH, NAD\(^+\), FAD, TPP (thiamine pyrophosphate), and lipoic acid. \(\text{Mg}^{2+}\) serves as a cofactor for the enzyme. Biotin is NOT involved — it is a cofactor for carboxylation reactions (e.g., pyruvate carboxylase), not decarboxylation.