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OPRA Medicinal Chemistry and Biopharmaceutics QUESTION #3818
Question 1
Why are viscosity-enhancing agents such as methylcellulose added to ophthalmic solutions?
  • To increase ocular exposure time✔️
  • To reduce inflammation of the eye by their soothing effect
  • To suspend soluble drugs
  • To reduce drop size
Correct Answer Explanation
Methylcellulose and similar agents increase the viscosity of ophthalmic drops, thereby prolonging contact time with the ocular surface and improving drug absorption.