Back to Questions
OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3831
Question 1
For a drug administered as a continuous intravenous infusion, which pharmacokinetic parameter does NOT affect the steady-state plasma concentration?
  • Dose
  • Drug clearance
  • Volume of distribution✔️
  • Dosing interval
Correct Answer Explanation
At steady state with IV infusion: $C_{ss} = \dfrac{\text{Dose rate}}{\text{Clearance}}$. Volume of distribution determines time to steady state but not the concentration itself. Dosing interval is irrelevant for continuous infusion.