Batch 1 contains 100 mg drug with 55% bioavailability. Batch 2 contains 200 mg with a relative bioavailability of 165%. What is the absolute bioavailability of Batch 2?

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OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3832

Question 1

Batch 1 contains $100$ mg drug with $55\%$ bioavailability. Batch 2 contains $200$ mg with a relative bioavailability of $165\%$. What is the absolute bioavailability of Batch 2?

$33.33\%$
$61.6\%$
$90.75\%$✔️
$300\%$

Correct Answer Explanation

Absolute bioavailability of Batch 2 $= \dfrac{165\% \times 55\%}{100} = 90.75\%$. The relative bioavailability is referenced against Batch 1's absolute bioavailability.

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