An adult receives 100 mg of a drug IV and achieves a plasma concentration of 2.5 mutext g/mL . Assuming uniform distribution in body water, what is the apparent volume of distribution?

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OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3836

Question 1

An adult receives $100$ mg of a drug IV and achieves a plasma concentration of $2.5\ \mu\text{g/mL}$. Assuming uniform distribution in body water, what is the apparent volume of distribution?

$0.4$ L
$4$ L
$40$ L✔️
$400$ L

Correct Answer Explanation

$V_d = \dfrac{\text{Dose}}{\text{Concentration}} = \dfrac{100\ \text{mg}}{2.5\ \mu\text{g/mL}} = \dfrac{100{,}000\ \mu\text{g}}{2.5\ \mu\text{g/mL}} = 40{,}000\ \text{mL} = 40\ \text{L}$.

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