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OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3842
Question 1
Which of the following drugs is eliminated from the body predominantly in an unchanged form without significant metabolic transformation?
  • Fluoxetine
  • Phenytoin
  • Codeine
  • Enalapril✔️
Correct Answer Explanation
Enalapril is primarily excreted unchanged by the kidneys (after minimal conversion to enalaprilat). Fluoxetine, phenytoin, and codeine all undergo significant hepatic metabolism.