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OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3844
Question 1
Which of the following beta-adrenoceptor blocking agents is primarily eliminated via renal excretion rather than hepatic metabolism?
  • Atenolol✔️
  • Metoprolol
  • Oxprenolol
  • Carvedilol
Correct Answer Explanation
Atenolol is predominantly renally cleared (approximately $85\%$ unchanged in urine), making it the beta-blocker most requiring dose adjustment in renal impairment.