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OPRA Pharmacokinetics and Pharmacodynamics QUESTION #3845
Question 1
Which enzymatic system in the liver is responsible for catalysing the biotransformation of phenobarbital?
  • By the oxidative phosphorylation complex
  • By the microsomal mixed function oxidases✔️
  • In the hexose monophosphate shunt
  • In the gluconeogenic pathway
Correct Answer Explanation
Phenobarbital is metabolised in the liver primarily by the cytochrome P450 system (microsomal mixed function oxidases), particularly CYP2C19.