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OPRA Pharmacology and Toxicology
QUESTION #3854
Question 1
Which co-administered drug poses the greatest risk of serotonin syndrome when combined with the reversible MAO-A inhibitor moclobemide?
Correct Answer Explanation
Sumatriptan is a serotonin agonist ($5\text{-HT}_{1\text{B}/1\text{D}}$). Combined with moclobemide, it can cause serotonin syndrome due to excessive serotonergic activity.
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