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OPRA Pharmacology and Toxicology QUESTION #3859
Question 1
Which mechanism accounts for the anticonvulsant action of phenytoin in reducing seizure activity?
  • Sodium channel blockade✔️
  • Binds to synaptic vesicle protein 2A
  • Binds to voltage-dependent calcium channels
  • Inhibits glutamate release
Correct Answer Explanation
Phenytoin stabilises neuronal membranes by blocking voltage-gated $\text{Na}^+$ channels, preventing the rapid repetitive firing of action potentials that underlies seizure propagation.