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OPRA Pharmacology and Toxicology QUESTION #3861
Question 1
By what primary mechanism does metformin exert its blood glucose-lowering effect in type 2 diabetes?
  • Blocks absorption of glucose in the intestine
  • Increases pancreatic insulin secretion
  • Decreases hepatic glucose production✔️
  • Increases metabolism of ketone precursors
Correct Answer Explanation
Metformin primarily reduces hepatic gluconeogenesis via AMPK activation, resulting in decreased hepatic glucose output and lower fasting blood glucose levels.