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OPRA Therapeutics and Patient Care QUESTION #3888
Question 1
A 50-year-old male treated for pitting oedema of the ankles subsequently develops gynaecomastia and erectile dysfunction. Which diuretic is most likely responsible for these endocrine adverse effects?
  • Hydrochlorothiazide
  • Furosemide
  • Spironolactone✔️
  • Triamterene
Correct Answer Explanation
Spironolactone is a mineralocorticoid antagonist with anti-androgenic effects. Its adverse effects include gynaecomastia, menstrual irregularities, and erectile dysfunction.