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OPRA Therapeutics and Patient Care QUESTION #3898
Question 1
In a patient with a confirmed sulfonamide allergy, cross-reactivity is least likely to occur with which of the following medications?
  • Hydrochlorothiazide
  • Sulfasalazine
  • Celecoxib
  • Ciprofloxacin✔️
Correct Answer Explanation
Ciprofloxacin is a fluoroquinolone with no sulfonamide moiety and is the least likely of these options to show cross-reactivity. Hydrochlorothiazide, sulfasalazine, and celecoxib all contain sulfonamide-related structures.