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OPRA Therapeutics and Patient Care QUESTION #3899
Question 1
What is the most clinically important advantage of angiotensin II receptor blockers (ARBs) over ACE inhibitors in terms of tolerability?
  • There is a decreased incidence of hyperkalaemia
  • They are less likely to cause adverse effects such as dizziness
  • There is a reduced incidence of cough✔️
  • They do not interact with non-steroidal anti-inflammatory medications
Correct Answer Explanation
ACE inhibitors cause a dry persistent cough in up to $20\%$ of patients by increasing bradykinin levels. ARBs do not inhibit ACE and therefore have a significantly lower incidence of cough.