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OPRA Therapeutics and Patient Care QUESTION #3905
Question 1
Which medication is used as a uroprotective agent to prevent haemorrhagic cystitis in patients receiving cyclophosphamide chemotherapy?
  • Methotrexate
  • Mercaptopurine
  • Dacarbazine
  • Mesna✔️
Correct Answer Explanation
Mesna (sodium 2-mercaptoethane sulphonate) binds to acrolein, the urotoxic metabolite of cyclophosphamide, in the urine, neutralising it and preventing bladder toxicity.