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OPRA Therapeutics and Patient Care QUESTION #3907
Question 1
In which clinical condition should the dose of vancomycin be reduced to prevent drug accumulation and toxicity?
  • Pulmonary failure
  • Hepatic impairment
  • Heart failure
  • Renal impairment✔️
Correct Answer Explanation
Vancomycin is primarily renally excreted. In renal impairment, clearance is reduced, leading to drug accumulation, nephrotoxicity, and ototoxicity. Dose and/or frequency must be reduced.