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OPRA Therapeutics and Patient Care QUESTION #3912
Question 1
Which of the following can elevate plasma lithium levels and increase the risk of lithium toxicity?
  • Moderate exercise
  • Salt-intake reduction✔️
  • Smoking cessation
  • Hypothyroidism
Correct Answer Explanation
Sodium depletion (from low-salt diet, diuretics, vomiting, or excessive sweating) causes the kidney to reabsorb more lithium along with sodium, increasing plasma lithium levels and toxicity risk.