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PTECH Pharmacology QUESTION #5753
Question 1
In the brain, why can only lipid-soluble drugs cross the capillary endothelial cells into the CNS?
  • Due to large slit junctions
  • Because the basement membrane is exposed
  • Due to the absence of slit junctions✔️
  • Because of active transport of all water-soluble drugs
Correct Answer Explanation
Brain capillaries have continuous endothelial cells with no slit junctions, creating a barrier for polar molecules.