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MBBS QUESTION #10220
Question 1
The sodium-glucose cotransporter (SGLT) in the renal proximal tubule and intestinal brush border moves glucose against its concentration gradient by coupling it to sodium movement down the Na+ gradient (itself maintained by the Na+/K+-ATPase). This transport process is best classified as:
  • Simple diffusion
  • Facilitated diffusion
  • Primary active transport
  • Secondary active transport✔️
Correct Answer Explanation
SGLT does not directly hydrolyze ATP; instead it harnesses the electrochemical Na+ gradient established by the primary active Na+/K+-ATPase to drive glucose uptake against its own gradient — the definition of secondary active transport, and the physiological basis of SGLT2 inhibitor drugs in diabetes.