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MBBS QUESTION #10229
Question 1
A patient with chronic kidney disease develops normocytic normochromic anemia. The most direct physiological explanation is:
  • Reduced erythropoietin production by damaged renal peritubular interstitial cells✔️
  • Increased splenic sequestration and destruction of red cells
  • Vitamin B12 malabsorption
  • Chronic blood loss from the gastrointestinal tract
Correct Answer Explanation
Progressive nephron loss in chronic kidney disease reduces the renal mass responsible for erythropoietin synthesis, leading to inadequate erythropoietic stimulation and normocytic anemia — correctable with recombinant erythropoietin therapy.