Home › MCQs › MBBS › Question #10265
Back to Questions
MBBS QUESTION #10265
Question 1
Loop diuretics such as furosemide produce potent natriuresis and diuresis by directly inhibiting which renal transporter?
  • The Na+/K+/2Cl- cotransporter (NKCC2) in the thick ascending limb of the loop of Henle✔️
  • The Na+/Cl- cotransporter in the distal convoluted tubule
  • The epithelial sodium channel (ENaC) in the principal cells of the collecting duct
  • The Na+/glucose cotransporter (SGLT2) in the proximal tubule
Correct Answer Explanation
By blocking NKCC2 in the thick ascending limb, loop diuretics prevent reabsorption of a large fraction of filtered sodium (and disrupt the medullary concentration gradient), producing the most potent diuresis of any diuretic class — in contrast to thiazides (distal convoluted tubule Na+/Cl- cotransporter) and potassium-sparing diuretics (ENaC or aldosterone antagonism).