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MBBS QUESTION #10267
Question 1
Gastrin, secreted by G cells of the gastric antrum in response to luminal peptides and vagal stimulation, primarily acts to:
  • Stimulate gastric acid secretion by parietal cells (directly and via histamine release from ECL cells)✔️
  • Stimulate bicarbonate secretion from pancreatic duct cells
  • Stimulate bile secretion directly from hepatocytes
  • Stimulate insulin secretion from pancreatic beta cells
Correct Answer Explanation
Gastrin is the principal hormonal stimulus for gastric acid secretion, acting both directly on parietal cell CCK-B receptors and indirectly by stimulating enterochromaffin-like (ECL) cells to release histamine, which further potentiates acid secretion.