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MBBS QUESTION #10268
Question 1
A patient with Zollinger-Ellison syndrome (a gastrin-secreting tumor) develops multiple, refractory, and atypically located peptic ulcers. This clinical picture is best explained by:
  • Autonomous, unregulated gastrin secretion driving continuous excessive gastric acid production that overwhelms mucosal defenses✔️
  • A primary deficiency of gastrin, weakening the gastric mucosal barrier
  • Excess somatostatin secretion suppressing acid production
  • Helicobacter pylori infection as the sole causative mechanism
Correct Answer Explanation
Gastrinomas secrete gastrin independent of normal negative feedback (which would otherwise be suppressed by low gastric pH), driving sustained parietal cell hyperstimulation and severe acid hypersecretion, overwhelming mucosal protective mechanisms and producing multiple, often treatment-resistant ulcers.