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MBBS QUESTION #10273
Question 1
A patient shows flaccid weakness, absent or reduced deep tendon reflexes, marked muscle wasting, and fasciculations in the affected muscles. This clinical pattern is most consistent with a lesion of:
  • An upper motor neuron
  • A lower motor neuron (anterior horn cell, root, or peripheral nerve)✔️
  • The basal ganglia
  • The cerebellum
Correct Answer Explanation
Lower motor neuron lesions disconnect muscle from its trophic and reflex-arc innervation, producing flaccid paralysis, hyporeflexia/areflexia, prominent wasting (denervation atrophy), and fasciculations — as seen in poliomyelitis, peripheral neuropathy, or motor neuron disease affecting anterior horn cells.