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MBBS QUESTION #10275
Question 1
A patient develops resting tremor, cogwheel rigidity, and bradykinesia. This clinical triad results from degeneration of dopaminergic neurons in which structure?
  • The substantia nigra pars compacta✔️
  • The subthalamic nucleus
  • The external segment of the globus pallidus
  • The cerebellar dentate nucleus
Correct Answer Explanation
Parkinson's disease results from progressive loss of dopaminergic neurons in the substantia nigra pars compacta, reducing dopaminergic input to the striatum and disrupting the normal balance of the direct and indirect basal ganglia motor pathways — producing the classic triad of resting tremor, rigidity, and bradykinesia.