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MBBS QUESTION #10288
Question 1
Sheehan's syndrome, resulting from postpartum pituitary infarction after severe obstetric hemorrhage, classically presents with:
  • Isolated hyperthyroidism with no other hormonal deficiency
  • Panhypopituitarism, often first noticed as failure of lactation (agalactorrhea) due to loss of prolactin, along with other anterior pituitary hormone deficiencies✔️
  • Excessive ACTH production with hyperpigmentation
  • Isolated diabetes insipidus with entirely normal anterior pituitary function
Correct Answer Explanation
Severe postpartum hemorrhage and hypotension can cause ischemic infarction of the enlarged, hyperemic postpartum pituitary gland, producing panhypopituitarism; failure to lactate (due to prolactin deficiency) is often the first clinical clue, followed by features of thyroid, adrenal, and gonadal hormone insufficiency.