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MBBS QUESTION #10289
Question 1
A patient with primary hypothyroidism due to autoimmune (Hashimoto's) thyroiditis shows which characteristic hormonal pattern on laboratory testing?
  • Low TSH with high free T4
  • High TSH with low free T4, reflecting loss of negative feedback inhibition on the anterior pituitary✔️
  • Low TSH with low free T4
  • High TSH with high free T4
Correct Answer Explanation
In primary thyroid failure, reduced thyroid hormone output removes the normal negative feedback on the pituitary, causing compensatory elevation of TSH alongside low free T4 — the opposite pattern (low TSH, low T4) would suggest secondary (pituitary) hypothyroidism instead.