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MBBS QUESTION #10303
Question 1
Serum protein electrophoresis, used clinically to detect abnormal protein bands such as a monoclonal spike in multiple myeloma, separates plasma proteins primarily based on their:
  • Molecular weight and density via sedimentation
  • Charge-to-mass ratio and size under an applied electric field✔️
  • Affinity for a stationary chromatographic matrix
  • Absorbance of specific wavelengths of light
Correct Answer Explanation
Electrophoresis separates charged molecules by their migration rate through a supporting medium under an electric field, a rate determined by charge, size, and shape — the basis for detecting abnormal albumin/globulin band patterns, including the monoclonal gammopathy spike of multiple myeloma.