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MBBS QUESTION #10315
Question 1
Arachidonic acid, released from membrane phospholipids by phospholipase A2, is the principal precursor for which class of biologically active lipid mediators, including prostaglandins, thromboxanes, and leukotrienes?
  • Steroid hormones
  • Eicosanoids✔️
  • Sphingolipids
  • Bile acids
Correct Answer Explanation
Eicosanoids — prostaglandins (via cyclooxygenase), thromboxanes, and leukotrienes (via lipoxygenase) — are synthesized from the 20-carbon polyunsaturated arachidonic acid, mediating inflammation, platelet aggregation, bronchoconstriction, and other local signaling effects; NSAIDs inhibit cyclooxygenase to reduce prostaglandin/thromboxane synthesis.