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MBBS QUESTION #10341
Question 1
Endergonic biochemical reactions, which require a net input of free energy to proceed, are frequently made favorable within cells by coupling them to which highly exergonic reaction?
  • Hydrolysis of ATP to ADP and inorganic phosphate✔️
  • Synthesis of ATP from ADP and inorganic phosphate
  • Simple diffusion of ions down their electrochemical gradient, unrelated to ATP
  • Denaturation of cellular proteins
Correct Answer Explanation
Cells commonly couple an otherwise unfavorable (endergonic) reaction to the highly exergonic hydrolysis of ATP, making the combined (coupled) reaction thermodynamically favorable overall — the fundamental energetic strategy underlying most biosynthetic and active transport processes.