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MBBS QUESTION #10345
Question 1
Lactate produced by actively exercising skeletal muscle is transported to the liver, converted back to glucose via gluconeogenesis, and returned to muscle as glucose for further use. This inter-organ metabolic cycle is known as the:
  • Cori cycle✔️
  • Urea cycle
  • Citric acid (Krebs) cycle
  • Pentose phosphate pathway
Correct Answer Explanation
The Cori cycle describes this lactate-glucose shuttle between exercising muscle (or red blood cells) and the liver, allowing continued glucose supply to tissues that generate lactate faster than it can be oxidized locally, at the metabolic cost of ATP consumed during hepatic gluconeogenesis.