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MBBS QUESTION #10355
Question 1
HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis and the pharmacological target of statin medications, catalyzes conversion of HMG-CoA to:
  • Mevalonate✔️
  • Acetoacetate
  • Squalene
  • Lanosterol
Correct Answer Explanation
HMG-CoA reductase catalyzes the committed, rate-limiting step of cholesterol synthesis — reduction of HMG-CoA to mevalonate; statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis and upregulating LDL receptor expression to lower circulating LDL cholesterol.