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MBBS QUESTION #10356
Question 1
Chylomicrons, the largest and least dense of the plasma lipoproteins, are primarily responsible for transporting:
  • Endogenously synthesized cholesterol and triglycerides from the liver to peripheral tissues
  • Dietary (exogenous) triglycerides absorbed from the intestine, delivering them to peripheral tissues and eventually the liver✔️
  • Cholesterol from peripheral tissues back to the liver (reverse cholesterol transport)
  • Free fatty acids bound directly to circulating albumin
Correct Answer Explanation
Chylomicrons are assembled in intestinal enterocytes to package dietary (exogenous) triglycerides and cholesterol absorbed after a meal, delivering triglycerides to peripheral tissues (via lipoprotein lipase) before the remnant particle is cleared by the liver — distinct from VLDL, which instead transports endogenously synthesized (hepatic) triglycerides.