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MBBS QUESTION #10368
Question 1
A point mutation changes a single DNA base such that a codon specifying one amino acid now specifies a different amino acid, without altering overall protein length. This type of mutation is termed a:
  • Missense mutation✔️
  • Nonsense mutation
  • Silent mutation
  • Frameshift mutation
Correct Answer Explanation
A missense mutation alters a codon so that it encodes a different amino acid, potentially changing protein structure/function (as in sickle cell disease), in contrast to a silent mutation (no amino acid change), a nonsense mutation (premature stop codon), or a frameshift mutation (insertion/deletion shifting the reading frame).