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MBBS QUESTION #10375
Question 1
Insulin's overall biochemical effects on carbohydrate, lipid, and protein metabolism are best summarized as:
  • Predominantly catabolic, promoting glycogenolysis, lipolysis, and proteolysis throughout the body
  • Predominantly anabolic, promoting glycogen synthesis, lipogenesis, and protein synthesis while simultaneously inhibiting their respective catabolic pathways✔️
  • Having essentially no effect on lipid metabolism
  • Acting solely to raise circulating blood glucose concentration
Correct Answer Explanation
Insulin is the body's principal anabolic hormone, promoting glucose uptake and storage as glycogen, fat synthesis and storage (lipogenesis), and amino acid uptake with protein synthesis, while simultaneously suppressing glycogenolysis, lipolysis, and gluconeogenesis — its deficiency or resistance (as in diabetes mellitus) produces the opposite, catabolic metabolic state.