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Sudden Infant Death Syndrome (SIDS) โ sudden, unexplained death of an infant under 1 year during sleep, remaining unexplained after thorough investigation.
Peak age: 2โ4 months. Rare after 6 months.
Evidence-based SIDS Prevention (AAP Safe Sleep Guidelines 2022):
| Recommendation | Evidence Level |
|---|---|
| Supine (back) sleeping position โ always | Strongest evidence โ reduces SIDS by ~50% |
| Firm, flat sleep surface (crib/bassinet) | Strong โ no soft mattresses, pillows, bumpers |
| Room-sharing (parent's room) WITHOUT bed-sharing | Strong โ bed-sharing increases risk |
| Avoid smoke exposure (prenatal + postnatal) | Strong โ smoking is major modifiable risk factor |
| Avoid overheating | Moderate โ keep room 20โ22ยฐC |
| Breastfeeding | Moderate โ protective effect |
| Pacifier use at sleep (after BF established) | Moderate โ protective |
Prone sleeping increases SIDS risk 3โ9 fold. The 'Back to Sleep' campaign reduced SIDS deaths by >50% since 1992.
A compound with molecular mass 180 is acylated with CH$_3$COCl to yield a compound with molecular mass 390. How many amino ($-\text{NH}_2$) groups does the original compound contain?
Acylation: each $-\text{NH}_2$ reacts with CH$_3$COCl to introduce a $-\text{COCH}_3$ group ($M = 42$) and release HCl.
Net mass added per amino group $= 42 - 1 = 42$ (the $-H$ is replaced by $-\text{COCH}_3$)
Wait โ each NH$_2$ + CH$_3$COCl โ NH$\cdot$COCH$_3$ + HCl. Mass change per group $= 42 - 1 = +41$... more precisely: $-NH_2$ (16) becomes $-NHCOCH_3$ (58): increase = 42.
Increase in mass $= 390 - 180 = 210$
Number of amino groups $= \dfrac{210}{42} = \mathbf{5}$
The concept of 'Historical Materialism' is most closely associated with which thinker?
Karl Marx used historical materialism to explain the evolution of society through class struggle.
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